He published more than papers in the field of ncRNAs in cardiovascular diseases. Shashi Kumar Gupta, Dr. The new TRAIN Project is specifically focusing on drugs that might limit the pathological heart growth caused by myocardial infarction or high blood pressure. Johan Lorenzen and colleagues identified a new mechanism of acute kidney injury based on dysregulation of miR For the first time the ESC Scientists of Tomorrow and the HFA Heart Failure Specialists of Tomorrow were invited to create each one specific session to increase the visibility also for young active cardiovascular scientists and clinicians. With more than active participants the meeting was the so far largest meeting of the Working Groups and a great success.

Ankita presented her work characterising mineralocorticoid receptor induced cardiac remodeling, whilst Michael introduced his PhD project on the role of circRNAs in hypertrophic cardiomyopathy induced heart failure. The details about this work can be found here: Thus, miR could be of therapeutic interest to treat elderly individuals with myocardial infarction in near future. Both achievements highlight the importance and relevance of their work in the wider scientific field. This approach may substantially improve the diagnosis and provide prognostic information about patients affected by MS.

For more information, please visit https: Thomas Thum and Dr.

mhh dissertation 2012

He aims to develop and test microRNA based therapies in small and large animal models of myocardial infarction and congestive heart failure. The journal focuses on fundamental research, translational research, translational science, and clinical research on all topics pertaining to cardiovascular system issues. These results suggest an involvement of miR in age-associated cardiac changes, such as cardiac fibrosis.

Mit einer neuen Methode gelang es mhy, rund 4. In this year, three MHH researchers were eissertation including Dr.


mhh dissertation 2012

In vivo, pressure overload of the left ventricle led to increased expression of miR in sorted cardiac endothelial cells, which displayed molecular and phenotypic signs of EndMT Figure.

Jan Fiedler and Ariana Foinquinos in Dresden. Endurance, curiosity, creativity – we can learn a lot from children. Both researchers have a budget of about July The Physiological Society invited Dr.

Work Group Leaders – REBIRTH Cluster of Excellence

Ariana Foinquinos won the 2 nd prize in the Young Investigator Award session for her presentation on the development of a novel treatment for heart failure after myocardial infarction based on AntimiR delivery. Importantly, the miRNA patterns differentiated relapsing-remitting from secondary progressive MS courses with enormous specificity and sensitivity. Small interference RNA-mediated silencing of mimecan in cardiac fibroblasts mimicked the miRmediated effects.

mhh dissertation 2012

For further information please see the following web pages: Fabian Kreutzer presented in the AWARD session, sponsored by NovoNordisk, among the 5 best abstracts in translational science shown together with the other junior scientists and with Prof. The overall aim is the development dossertation an improved diagnostic and therapeutic treatment strategy for patients after MI.

View this article on PubMed. It was never observed in humans before, but already known from newborn mice. This study paves a way for future miRNA based therapeutics for treatment of heart failure patients.

Urinary miR level identify patients with acute rejection and predict long-term kidney function. This intensive 2 years program included different modules aiming to understand the finding, development and clinical application of novel drug targets. Overall, these results indicate miR promotes renal ischemic injury by stimulating apoptosis in endothelial and tubular epithelial cell.

This study highlights the potential use of miR as a diagnostic and therapeutic candidate for cardiovascular diseases. Ariana Foinquinos won the 2 nd prize in the Young Investigator Award session for her presentation on the Pharmacological microRNA modulation for the treatment of heart failure.


April Physiological aging and senescence are associated to progressive decline in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases.

MiR induces endothelial cell apoptosis, abolishes endothelial capillary network formation. Initial lncRNA screening was performed in plasma RNA from patients with myocardial infarction according to the level of left ventricular LV remodeling.

State-of-the-art technologies, especially high-throughput methods, as diseertation as an international network are an important basis for the successful development. This will considerably strengthen cooperative research between the Medical School Hannover and the Imperial College in London in terms of heart failure and transplantation research.

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MiR effects were mediated through regulation of H2A histone family, member X, and heme oxygenase 1, which were experimentally validated as direct miR targets. In the other part of his work, he also focussed on evaluation of circulating microRNAs as diagnostic and prognostic biomarker for patients with acute myocardial infarction. This year an Excellent Paper was selected for the Cardiovascular Research Award EPCA with the idea to identify excellent work in the field of cardiovascular sciences and to promote young scientists.

Meox2-specific silencing mimicked the effects of this miRNA family on reprogramming.